[Frontiers in Bioscience 12, 2050-2062, January 1, 2007] 2050 Megakaryopoiesis: Transcriptional Insights into Megakaryocyte Maturation
نویسندگان
چکیده
1. Abstract 2. Introduction 3. Signaling Pathways Involved in Megakaryocyte Maturation 3.1. Thrombopoietin 3.2. TPO-Initiated Signaling in Megakaryocytes 3.3. Phosphatidylinositol 3-kinase 3.4. Mitogen Activated Protein Kinases 3.5. Stromal Cell-Derived Factor 1 3.6. Immediate Early Gene X-1 3.7. The Src Family Kinase; Lyn 4. Transcription Factors Associated with Megakaryopoiesis 4.1. GATA-1 and Its Cofactor FOG-1 4.2. Friend of GATA-1 4.3. Other GATA-1 Interactions 4.4. AML1/RUNX1 and Its Interactions Observed in Megakaryopoiesis 4.5. Nuclear Factor Erythroid-Derived 2 4.6. Other Factors Involved in Megakaryopoiesis 4.7. The Transcription Factor Fli-1 4.8. The Cap’n’colar BACH1 5. Summary 6. Acknowledgement 7. References
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